Nanobubble technology is a convenient therapy that helps to immediately increase your tissues local oxygen concentration. Simply put your foot inside a transparent bootie that is partially filled with our nanobubbled gel, leave it on for 20-30 minutes, pull out foot, wipe clean and the treatment is finished. Relief is often observed after the first treatment, but may take 2-3 treatments for significant improvement. When first using NoxyPure a treatment is performed once a day for the first 3 days then repeated every other day for 10 more days (total of 8 treatments) to get several weeks of relief. When symptoms resurface (usually after 4-6 weeks) follow-up treatments require just 5 applications, with one treatment being done every other day, over 10 days.